The Wittig reaction is used as a model reaction to monitor the outflow of a microreactor during predetermined intervals, using an inline HPLC method. A conventional Shimadzu HPLC system was coupled to the FlowStart B-200 microreactor system with a 6-port valve, which was automatically controlled by the HPLC software. This setup provided continuous, automated feedback on the conversion and stability of the process, without the need for sample-taking and subsequent work-up steps.

 
FlowStart setup with 6-port valve connection in loop-mill mode

The application note describes the automated analysis of a continuous flow process using the FlowStart B-200 and a Shimadzu LC2010 HPLC system.

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