Our patented technology proved to be successful in organic synthetic reactions, such as oxidations, protecting group transformations and biocatalysed C-C bond formations.
Selection of Publications
[1] B.A.M.W. van den Broek, R. Becker, F., M.M. E. Delville, P.J. Nieuwland, K. Koch and F.P.J.T. Rutjes; Prilezhaev Dihydroxylation of Olefins in a Continuous Flow Process, ChemSusChem, 2012, Early View
PDF http://dx.doi.org/10.1002/cssc.201100342
[2] B.A.M.W. van den Broek, J.Leliveld, R., M.M.E Delville, P.J. Nieuwland, Kaspar Koch, and F. P. J. T. Rutjes
Continuous flow production of thermally unstableintermediates in a microreactor with line IR-analysis:controlled Vilsmeier-Haack formylation of electron-rich arenes, 2012, OPRD, Just accepted
PDF http://dx.doi.org/10.1021/op2003437
[3] I. Dencic, V. Hessel, M.H.J.M. de Croon, J. Meuldijk, C.W.J. van der Doelen and K. Koch; Recent Changes in Patenting Behavior in Microprocess Technology and its Possible Use for Gas–Liquid Reactions and the Oxidation of Glucose, ChemSusChem, 2012, early view
PDF http://dx.doi.org/10.1002/cssc.201100389
[4] P.J. Nieuwland, R. Segers, K. Koch, J.C.M. van Hest and F.P.J.T. Rutjes; Fast Scale-Up Using Microreactors: Pyrrole Synthesis from Micro to Production Scale, Org. Process Res. Dev., 2011, 15 (4), pp 783–787.
PDF http://dx.doi.org/10.1021/op100338z
[5] R. Becker, K. Koch, P.J. Nieuwland and F.P.J.T. Rutjes; Flow chemistry today: practical approaches for optimisation and scale-up, Chimica Oggi, Chemistry Today. 2011, 29, 47-49
[6] M.M.E Delville, P.J. Nieuwland, P. Janssen, K. Koch, J.C.M. van Hest and F.P.J.T. Rutjes; Continuous flow azide formation: Optimization and scale-up, Chemical Engineering Journal, 2010, 167, 556-559.
PDF http://dx.doi.org/10.1016/j.cej.2010.08.087
[7] P.J. Nieuwland, K. Koch, N. van Harskamp, R. Wehrens, J.C.M. van Hest and F.P.J.T. Rutjes; Flash chemistry extensively optimized: high temperature Swern-Moffatt oxidation in an automated microreactor platform, Chemistry-an Asian Journal, 2010, 799-805.
PDF http://dx.doi.org/10.1002/asia.200900705
[8] P.J. Nieuwland, K. Koch, J.C.M. v. Hest and F.P.J.T. Rutjes; Flow markers in microreactors: a generally applicable chromatographic method for monitoring flow rates during reactions, The Open Chemical Engineering Journal, 2010, Volume 4.
PDF http://dx.doi.org/10.2174/1874123101004010061
[9] Catherine F. Carter, Heiko Lange, Steven V. Ley, Ian R. Baxendale, Brian Wittkamp, Jon G. Goode and Nigel L. Gaunt; ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing, Org. Process Res. Dev., 2010, 14 (2), 393-404.
PDF http://dx.doi.org/10.1021/op900305v
[10] K. Koch, B.J.A. van Weerdenburg, J.M.M. Verkade, P.J. Nieuwland, F.P.J.T. Rutjes and J.C.M. van Hest, Optimizing the Deprotection of the Amine Protecting p-Methoxyphenyl Group in an Automated Microreactor Platform, Org. Process Res. Dev., 2009, 13 (5), 1003-1006.
PDF http://dx.doi.org/10.1021/op900139u
[11] J. Bart, A.J. Kolkman, A.J. Oosthoek-de Vries, K. Koch, P.J. Nieuwland, J.W.G. Janssen, P.J.M. van Bentum, K.A.M. Ampt, F.P.J.T. Rutjes, S.S. Wijmenga, J.G.E. Gardeniers and A.P.M. Kentgens; A Microfluidic High-Resolution NMR Flow Probe, J. Am. Chem. Soc., Article, 2009, 5014.
PDF http://dx.doi.org/10.1021/ja900389x
[12] K. Koch, S.S. van Berkel, M.M.E.B. van de Wal, P.J. Nieuwland, J.C.M. van Hest, F.P.J.T. Rutjes, Thrombin generation test in microfluidic systems, Journal of applied physics, 2009, 105, 102012.
PDF http://dx.doi.org/10.1063/1.3116634
[13] K. Koch, F.P.J.T. Rutjes, J.C.M. van Hest, Microreactors in organic synthesis and catalysis, Chapter 4.4 Bio-organic reactions, Wiley VCH, 2008.
Link http://eu.wiley.com/
[14] K. Koch, R.J.F. van den berg, P.J. Nieuwland, R. Wijtmans, H. E. Schoemaker, J.C.M. van Hest, F.P.J.T. Rutjes, Enzymatic enantioselective C–C-bond formation in microreactors, Biotechnology and bioengineering, 2008, 99 (4), 1028-1033.
PDF http://dx.doi.org/10.1002/bit.21649
[15] K. Koch, R.J. F. van den Berg, P.J. Nieuwland, R. Wijtmans, M.G. Wubbolts, H.E. Schoemaker, F.P.J.T. Rutjes and J.C.M. van Hest, Enzymatic synthesis of optically pure cyanohydrins in microchannels using a crude cell lysate, Chemical Engineering Journal, 2008, 135, S89-S92.
[16] P,J. Nieuwland, K. Koch, J.C.M. van Hest and Floris P.J.T. Rutjes, Ionic liquids in a microreactor: palladium catalysis, Proceedings of µTAS 2006 Conference, Tokyo, Japan, 2006, 870-872.
[17] K. Koch, P. J. Nieuwland, H.E. Schoemaker, M.G. Wubbolts, F.P.J.T. Rutjes and J.C.M. van Hest, Screening multi-phase enzymatic reactions in a microreactor setup, Proceedings of µTAS 2006 Conference, Tokyo, Japan, 2006, 867-869.
[18] K. Koch, R.J.F. van den Berg, P.J. Nieuwland, J.C.M. van hest, F.P.J.T. Rutjes, Multi-phase enzymatic synthesis in microchannels, Proceedings of IMRET 9, 2006, 196-197.
[19] P.J. Nieuwland, K. Koch, M. Ueno, T. Kitamori, J.C.M. van Hest, F.P.J.T. Rutjes, Multi-Phase Two-Step Synthesis in Microreactors, Proceeding of µTAS 2005 Conference, Boston MA, USA 2005, 1434-1436.
[20] K. Koch, R.J.F. van den Berg, P.J. Nieuwland , M. Ueno, T, Kitamori, F.P.J.T. Rutjes and J.C.M. Van Hest, Improved Multi-Phase Enzymatic Synthesis in a Microchannel, Proceeding of µTAS 2005 Conference,, Boston MA, USA 2005, 924-926.
